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CATEGORY: ORIGINAL RESEARCH
Year : 2020  |  Volume : 20  |  Issue : 5  |  Page : 5

Transition metal oxide (in nanoform) modified polymer for Prosthodontic applications


Govt. Dental College, Kottayam, India

Date of Web Publication8-Jan-2021

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-4052.306354

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How to cite this article:
Raj I. Transition metal oxide (in nanoform) modified polymer for Prosthodontic applications. J Indian Prosthodont Soc 2020;20, Suppl S1:5

How to cite this URL:
Raj I. Transition metal oxide (in nanoform) modified polymer for Prosthodontic applications. J Indian Prosthodont Soc [serial online] 2020 [cited 2021 Jan 20];20, Suppl S1:5. Available from: https://www.j-ips.org/text.asp?2020/20/5/5/306354



Introduction: In this research work, procured ZnO and CuO nanoparticles were added to pure PMMA and nanocomposite films (PMMA/ZnO-PZ and PMMA/CuO-PC) were developed with the intention of overcoming this polymer's drawbacks. Any material developed with the intention of biomedical applications should be biocompatible and this should be tested to confirm its suitability with existing international standards. In this presentation; biocompatibility, antifungal and antimicrobial test results will be discussed in detail.

Methodology: Enzymatic assays were adopted for assessing toxicity of the procured nano particles. After developing nanocomposites biocompatibility of the developed composites (PZ and PC) were checked and results were compared with control and also with commercial dental PMMA utilizing various in vivo enzymatic assays and protein estimations. Anti fungal property against Candida albicans ATCC 10231 cells and antibacterial property against Streptococcus mutans were tested in vitro.

Result: 1.>75% of fibroblast on procured ZnO NPs in MTT assay. 2. Fluorescent microscopic images revealed fibroblast proliferations in all the samples. 3. Candidal colonies were found less on nanocomposite samples. 4. Less number of bacteriae (S. mutans) were seen on developed nanocomposites. 5. In Acetylcholine Esterase Enzyme study in mouse brain, both NPs found nontoxic. 6. In ALT, AST and AchE enzymatic assays no significant difference between control and experimental groups.

Conclusion: Research was concluded with fruitful outcome and can be suggested to have clinical trials after further animal studies.






 

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