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 Table of Contents  
CATEGORY: ORIGINAL RESEARCH
Year : 2020  |  Volume : 20  |  Issue : 5  |  Page : 8

Toxicity test for silver-zeolite: - An original research


Institute of Dental Sciences, Bhubaneswar, India

Date of Web Publication8-Jan-2021

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-4052.306362

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How to cite this article:
Panda SK. Toxicity test for silver-zeolite: - An original research. J Indian Prosthodont Soc 2020;20, Suppl S1:8

How to cite this URL:
Panda SK. Toxicity test for silver-zeolite: - An original research. J Indian Prosthodont Soc [serial online] 2020 [cited 2021 Jan 19];20, Suppl S1:8. Available from: https://www.j-ips.org/text.asp?2020/20/5/8/306362



Introduction: Silver-zeolite has emerged as an ideal molecule for imparting antibacterial and antifungal ability if incorporated in heat-cure denture base resin and tissue conditioners. However the toxicity of the molecule is yet to be ascertained to establish it as a safe molecule for incorporation. Therefore a toxicity test was performed in order confirm its biocompatibility.

Methodology: 5 different concentration of Silver-zeolite which have been previously established as having Anti-bacterial and Antifungal efficacy were evaluated using brine shrimp assay and lethal concentration value (Lc50) was determined.

Result: The LC25 (lethal concentration25) value was 1.6μg/ml, whereas the LC50 value was 1.77 μg/ml and the LC75 value was 1.90μg/ml,calculated from probit computational method.

Conclusion: Silver-zeolite has the potential to change the ongoing system and bring about a revolution as an Anti-microbial drug. However, the dose must be regulated as it can be toxic in higher concentrations.






 

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