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| CATEGORY: ORIGINAL RESEARCH |
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| Year : 2020 | Volume
: 20
| Issue : 5 | Page : 8 |
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Toxicity test for silver-zeolite: - An original research
Sangram Kumar Panda
Institute of Dental Sciences, Bhubaneswar, India
| Date of Web Publication | 8-Jan-2021 |
Correspondence Address:
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0972-4052.306362
How to cite this article:
Panda SK. Toxicity test for silver-zeolite: - An original research. J Indian Prosthodont Soc 2020;20, Suppl S1:8 |
Introduction: Silver-zeolite has emerged as an ideal molecule for imparting antibacterial and antifungal ability if incorporated in heat-cure denture base resin and tissue conditioners. However the toxicity of the molecule is yet to be ascertained to establish it as a safe molecule for incorporation. Therefore a toxicity test was performed in order confirm its biocompatibility.
Methodology: 5 different concentration of Silver-zeolite which have been previously established as having Anti-bacterial and Antifungal efficacy were evaluated using brine shrimp assay and lethal concentration value (Lc50) was determined.
Result: The LC25 (lethal concentration25) value was 1.6μg/ml, whereas the LC50 value was 1.77 μg/ml and the LC75 value was 1.90μg/ml,calculated from probit computational method.
Conclusion: Silver-zeolite has the potential to change the ongoing system and bring about a revolution as an Anti-microbial drug. However, the dose must be regulated as it can be toxic in higher concentrations.
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